DURECT Corporation Presenting at the Jefferies Healthcare Conference

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CUPERTINO, Calif., June 21, 2007 /PRNewswire-FirstCall via COMTEX News Network/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present at the Jefferies
Healthcare Conference being held in New York City. Matthew J. Hogan, Chief
Financial Officer, will be presenting at the conference on June 27, 2007 at
9:10 AM Eastern Time.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO)

A live audio webcast of the presentation will be available by accessing
DURECT’s homepage at http://www.www.durect.com and clicking “Investor Relations”.
If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”
section.

Webcast Link: http://www.wsw.com/webcast/jeff18/drrx

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company
developing pharmaceutical systems based on its proprietary drug delivery
platform technologies. The Company currently has a number of late-stage
pharmaceutical products in development addressing large markets in pain
management, with a number of research programs underway targeting chronic
disease and other therapeutic areas. For more information, please visit
http://www.www.durect.com.

SOURCE DURECT Corporation

Matthew J. Hogan, Chief Financial Officer of DURECT Corporation, +1-408-777-4936; or
media, Jeremiah Hall, Senior Vice President of Feinstein Kean Healthcare,
+1-415-677-2700, jeremiah.hall@fkhealth.com

http://www.www.durect.com

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